Publications

BioTechniques Cover 2015 Feb Issue

Enhanced assessment of contractile dynamics in Drosophila hearts. Cammarato A, Ocorr S, and Ocorr K. BioTechniques 58:77-80 (February 2015) doi 10.2144/000114255

A metabolic regulatory network centered on PGC-1/spargel modulates high-fat diet-induced cardiac lipotoxicity in Drosophila. Diop S, Bisharat-Kernizan J, Birse R, Oldham S, Ocorr K, Bodmer R (2015). Cell Reports S2211-1247(15)00168-0. doi: 10.1016/j.celrep.2015.02.022. PMID:25753422

Heart Specific ScoX Knockdown Induces p53 Dependent Apoptosis and a Cardiomyopathy in D. Melanogaster. Martinez-Morentin L, Martinez L, Piloto S, Yang H, Schon E, Garesse R, Bodmer R, Ocorr K*, Cervera M*, Arredondo J* (2015). Hum Mol Genet 2015 Mar 19. pii: ddv106. [Epub ahead of print] PMID:25792727 *Co-corresponding authors

Vinculin-network mediated cytoskeletal remodeling and regulation of contractile function in aging myocardium. Kaushik G, Spenlehauer A, Sessions AO, Trujillo AS, FuhrmannA, Fu Z, Venkatraman V, Pohl D, Tuler J, Wang M, Lakatta EG, Ocorr K, Bodmer R, Bernstein SI, Van Eyk JE, Cammarato A, Engler AJ (2015). SciTranslMed Jun17;7(292):292ra99. doi:10.1126/scitranslmed.aaa5843. PMID:26084806

Cardiac responses to hypoxia and reoxygenation in Drosophila. Zarndt R, Piloto S, Powell F, Haddad G, Bodmer R*, Ocorr K* (2015). Am J Physiol Regul Integr Comp Physiol 2015 Sep 16:ajpregu.00164.2015. doi: 10.1152/ajpregu.00164.2015. [Epub ahead of print] PMID:26377557 *Co-corresponding Authors (Editor‘s Pick for Dec 2015; selected for inclusiion in APS Select collection)

Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes. Ivy JR, Drechsler M, Catterson J, Bodmer R, Ocorr K, Paululat A., Hartley PS (2015). PLoS One 2015 Aug 24;10(8):e0134620. doi: 10.1371/journal.pone.0134620. eCollection 2015 PMID:26301956

Aging and CaMKII alter intracellular Ca2+ transients and heart rhythm in Drosophila melanogaster. Santalla M, Valverde CA, Harnichar E, Lacunza E, Aguilar-Fuentes J, Mattiazzi A, Ferrero P. PLoS One. 2014 Jul 8;9(7):e101871. doi: 10.1371/journal.pone.0101871. eCollection 2014. PMID: 25003749

Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart. Melkani GC, Trujillo AS, Ramos R, Bodmer R, Bernstein SI, Ocorr K. (2013) PLoS Genet. 2013;9(12):e1004024. doi: 10.1371/journal.pgen.1004024. Epub 2013 Dec 19. PMID: 24367279

Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. Heinrichsen ET, Zhang H, Robinson JE, Ngo J, Diop S, Bodmer R, Joiner WJ, Metallo CM, Haddad GG. Mol Metab. 2013 Oct 23;3(1):42-54. doi: 10.1016/j.molmet.2013.10.003. eCollection 2014 Feb. PMID: 24567903

Pygopus maintains heart function in aging Drosophila independently of canonical Wnt signaling. Tang M, Yuan W, Fan X, Liu M, Bodmer R, Ocorr K, Wu X. Circ Cardiovasc Genet. 2013 Oct;6(5):472-80. doi: 10.1161/CIRCGENETICS.113.000253. Epub 2013 Sep 17. PMID: 24046329

Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes. Rahman MM1, Sykiotis GP, Nishimura M, Bodmer R, Bohmann D. (2013) Aging Cell. Aug;12(4):554-62. doi: 10.1111/acel.12078. Epub 2013 May 16.

The conserved ADAMTS-like protein lonely heart mediates matrix formation and cardiac tissue integrity. Drechsler M, Schmidt AC, Meyer H, Paululat A. PLoS Genet. 2013;9(7):e1003616. doi: 10.1371/journal.pgen.1003616. Epub 2013 Jul 11. PMID: 23874219

In vivo cardiac reprogramming contributes to zebrafish heart regeneration. Zhang R, Han P, Yang H, Ouyang K, Lee D, Lin YF, Ocorr K, Kang G, Chen J, Stainier DY, Yelon D, Chi NC. Nature. 2013 Jun 27;498(7455):497-501. doi: 10.1038/nature12322. Epub 2013 Jun 19. PMID: 23783515

The NADPH metabolic network regulates human αB-crystallin cardiomyopathy and reductive stress in Drosophila melanogaster. Xie HB, Cammarato A, Rajasekaran NS, Zhang H, Suggs JA, Lin HC, Bernstein SI, Benjamin IJ, Golic KG. PLoS Genet. 2013 Jun;9(6):e1003544. doi: 10.1371/journal.pgen.1003544. Epub 2013 Jun 20. PMID: 23818860

Multiplexin promotes heart but not aorta morphogenesis by polarized enhancement of slit/robo activity at the heart lumen. Harpaz N, Ordan E, Ocorr K, Bodmer R, Volk T.(2013) PLoS Genet. 2013 Jun;9(6):e1003597. doi: 10.1371/journal.pgen.1003597. Epub 2013 Jun 27. PMID: 23825967

Fermitins, the orthologs of mammalian Kindlins, regulate the development of a functional cardiac syncytium in Drosophila melanogaster. Catterson JH, Heck MM, Hartley PS. ( 2013) PLoS One. 2013 May 15;8(5):e62958. doi: 10.1371/journal.pone.0062958. PMID: 23690969

Complex genetic architecture of cardiac disease in a wild type inbred strain of Drosophila melanogaster. Zhang Z, Hsieh B, Poe A, Anderson J, Ocorr K, Gibson G, Bodmer R. PLoS One. 2013 Apr 29;8(4):e62909. doi: 10.1371/journal.pone.0062909. Print 2013. PMID: 23638165

A Drosophila model of high sugar diet-induced cardiomyopathy. Na J, Musselman LP, Pendse J, Baranski TJ, Bodmer R, Ocorr K, Cagan R. PLoS Genet. 2013;9(1):e1003175. doi: 10.1371/journal.pgen.1003175. Epub 2013 Jan 10. PMID: 23326243

dJun and Vri/dNFIL3 are major regulators of cardiac aging in Drosophila. Monnier V, Iché-Torres M, Rera M, Contremoulins V, Guichard C, Lalevée N, Tricoire H, Perrin L. PLoS Genet. 2012;8(11):e1003081. doi: 10.1371/journal.pgen.1003081. Epub 2012 Nov 29. PMID: 23209438

Zebrafish: a novel research tool for cardiac (patho)electrophysiology and ion channel disorders. Verkerk AO, Remme CA. Front Physiol. 2012 Jul 10;3:255. doi:10.3389/fphys.2012.00255. eCollection 2012. PMID:22934012

Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation. Spindler SR, Li R, Dhahbi JM, Yamakawa A, Mote P, Bodmer R, Ocorr K, Williams RT, Wang Y, Ablao KP. PLoS One. 2012;7(6):e39581. doi: 10.1371/journal.pone.0039581. Epub 2012 Jun 21. PMID:22737247

In situ mechanical analysis of myofibrillar perturbation and aging on soft, bilayered Drosophila myocardium. Kaushik G, Fuhrmann A, Cammarato A, Engler AJ. (2011) Biophys J. Dec 7;101(11):2629-37. doi: 10.1016/j.bpj.2011.10.042. PMID: 22261050

Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R. (2011) J Cell Biol. Jun 27;193(7):1181-96. doi: 10.1083/jcb.201006114. Epub 2011 Jun 20. PMID: 21690310

The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart model. Melkani GC, Bodmer R, Ocorr K, Bernstein SI. (2011) PLoS One. 2011;6(7):e22579. PMID: 21799905

Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila. Lim HY, Wang W, Wessells RJ, Ocorr K, Bodmer R. (2011) Genes Dev. Jan 15;25(2):189-200. doi: 10.1101/gad.1992411.

High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila. Birse RT, Choi J, Reardon K, Rodriguez J, Graham S, Diop S, Ocorr K, Bodmer R, Oldham S. (2010) Cell Metab. Nov 3;12(5):533-44. doi: 10.1016/j.cmet.2010.09.014.

A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmén L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NN, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks AA, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM. (2010) Cell. Apr 2;141(1):142-53. doi: 10.1016/j.cell.2010.02.023. PMID: 20371351

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. (2010) Science. Mar 5;327(5970):1223-8. doi: 0.1126/science.1182228. PMID: 20203043

Semi-automated Optical Heartbeat Analysis of small hearts. Ocorr K, Fink M, Cammarato A, Bernstein S, Bodmer R. (2009) J Vis Exp. Sep 16;(31). pii: 1435. doi: 10.3791/1435. PMID: 19759521

d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila. Wessells R, Fitzgerald E, Piazza N, Ocorr K, Morley S, Davies C, Lim HY, Elmén L, Hayes M, Oldham S, Bodmer R. Aging Cell. 2009 Sep;8(5):542-52. doi: 10.1111/j.1474-9726.2009.00504.x. Epub 2009 Jul 9. PMID: 19594484

Partial loss of GATA factor Pannier impairs adult heart function in Drosophila. Qian L, Bodmer R. (2009) Hum Mol Genet. Sep 1;18(17):3153-63. doi: 10.1093/hmg/ddp254. Epub 2009 Jun 3. PMID: 19494035

A new method for the detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts. Fink M, Callol-Massot C, Chu A, Ruiz-Lozano P, Belmonte JC, Giles W, Bodmer R, and Ocorr K (2009). Biotechniques 46:101-113. PMID: 19317655

Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype. Taghli-Lamallem O, Akasaka T, Hogg G, Nudel U, Yaffe D, Chamberlain JS, Ocorr K, Bodmer R. Aging Cell. 2008 Mar;7(2):237-49. doi: 10.1111/j.1474-9726.2008.00367.x. Epub 2008 Jan 23. PMID: 18221418

Myosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac muscles. Cammarato A, Dambacher CM, Knowles AF, Kronert WA, Bodmer R, Ocorr K, Bernstein SI. (2008) Mol Biol Cell. Feb;19(2):553-62. Epub 2007 Nov 28. PMID: 18045988

KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging. Ocorr K, Reeves N, Wessells RJ, Fink M, Chen H-SV, Akasaka T, Yasuda S, Metzger J, Giles W, Posakony JW, and Bodmer R (2007) Proc Natl Acad Sci USA 104:3943-8. PMID: 17360457